If you have a lot of folders or subfolders, then again you may face profile issues. Another reason is when the size of the PST file maxes out sometimes the size of a PST is limited, and when users hit the limit, they face profile corruption. Sometimes due to a corrupted PST, the profile becomes inaccessible, and it needs repair. One of the many reasons for Outlook profile corruption is a corrupted PST.
Try automated tool Kernel for Outlook PST Repair to repair corrupt PST file and fix Outlook PST error issues.